Innovative
Collagen
Hydrogel

For the non-surgical treatment
of periodontal and
peri-implant inflammation

 

PROPERTIES: WHY H42® IS A UNIQUE PRODUCTH42® is an innovative collagen hydrogel with controlled biological properties, consistency and adhesiveness, enabling it to adapt perfectly to the geometry of the space into which it is inserted.

H42® is the result
of unique technology

H42® is the result of Exur-Teck®, a unique and innovative technological process developed by Bioteck®, which enables the combination of natural components, such as equine collagen, with resorbable polymers and trace amounts of ascorbic acid, which acts as a viscosity-modulating agent.

* The needle is not included in the product packaging.

PROPERTIES: WHY H42® IS A UNIQUE PRODUCT

  • ITS VISCOELASTICITY allows it to adapt perfectly to the geometry of peri-implant and periodontal pockets.
  • RESORBABLE: following a single application, it does not need to be removed; it is naturally eliminated without leaving any residue.
  • FILLS UP TO 4-6 periodontal/peri-implant pockets in a single treatment session.
  • VERSATILE: it is used for both periodontal and peri-implant pockets.
  • COMPATIBLE WITH A WIDE
    RANGE OF NEEDLES:
    H42® can be administered using various types of needles with a diameter between 20 and 27 G, fitted with a Luer lock connector.
  • UNIQUE COMPOSITION based on natural collagen, vitamin C and resorbable polymers.

Benefits

  • PREVENTS BACTERIAL
    RECOLONISATION
  • PROMOTES THE NATURAL HEALING OF GUM TISSUE
  • EASY TO MANAGE
  • EASY TO USE

when is it used?

H42® is an innovative collagen hydrogel used as an adjunct in the non-surgical treatment of periodontal and peri-implant conditions, such as gingivitis, periodontitis, mucositis and peri-implantitis.

  • GengiviteGengivits
  • MucositeMucosits
  • ParodontiteParodontitis
  • PerimplantitePerimplantitis

HOW TO USE:
JUST A SINGLE APPLICATION IS ALL IT TAKES
TO ENJOY ALL THE BENEFITS OF H42®

  • POCKET IDENTIFICATION
  • REMOVAL OF BIOFILM
  • REMOVAL OF MINERALISED DEPOSITS
  • BACTERICIDE TREATMENT (OPTIONAL)
  • POCKET FILLING WITH H42®

Following site-specific non-surgical periodontal treatment of the tooth or implant to be treated
– and any further decontamination – proceed to thoroughly dry the site.
Next, fill the pocket by extruding H42® from the syringe, starting from the base of the pocket.
It is essential to avoid saliva contamination for the next 5 minutes (setting time) to ensure optimal adhesion of H42® to the tissues.
The application of H42® does not in any way alter the usual post-operative instructions following
non-surgical mechanical instrumentation.

Scientific evidence

PERIODONTITIS

Pocket depth reduction (PPD)

Riduzione della profondità di tasca nelle parodontiti, da 0 a 12 settimane. Grafico fornito dal cliente.

Graphs relating to a prospective, multicentre study involving 153 pockets with stage III periodontitis and an initial mean PPD of 5.73 mm (ranging from 5–8 mm). PPD was reduced by an average of 2.86 mm, with resolution of inflammation in 54% of cases.
Inflammation

Infiammazione nelle parodontiti: proporzioni a 0, 7, 14, 21 e 30 giorni. Grafico fornito dal cliente.

Roncati M., Fiorini E., Brera F., Brera M., Parma-Benfenati L., ClinicalTrials.gov ID NCT07592377
H42® as a therapeutic aid in advanced cases of periodontitis:
a conservative alternative which, in some cases, can avoid the need for surgery
Riduzione della PPD in 25 siti con una PPD iniziale di 7-8 mm. Grafico fornito dal cliente.
Reduction in PPD at 25 sites with an initial PPD of 7-8 mm, at various stages of treatment.
Valutazione clinica della PPD al basale.Valutazione clinica della PPD dopo 12 settimane.

Clinical assessment of PPD at baseline and after 12 weeks. The probe showed a reduction in PPD from 8 mm to 3 mm. Courtesy of Dr Marisa Roncati, Ferrara (IT).

PERI-IMPLANTITIS

Pocket depth reduction (PPD)

Riduzione della profondità di tasca nelle perimplantiti, da 0 a 12 settimane. Grafico fornito dal cliente.

Graphs relating to a multicentre retrospective study involving 23 pockets with severe peri-implantitis. With an initial mean PPD of 6 mm, a reduction of approximately 2 mm and resolution of inflammation were observed in 86% of cases.
Inflammation

Infiammazione nelle perimplantiti: proporzioni a 0, 7, 14, 21, 30 e 90 giorni. Grafico fornito dal cliente.

De Rosa N, Papa G, Tarquini G., ClinicalTrials.gov ID NCT07700628

Product range

H42®

H42-104 Hydrogel Oral – 1 syrs 0.4 cc
H42-304 Hydrogel Oral – 3 syrs 0.4 cc/syr

Marcatura CE 0477

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